Human Sera
Cayman Chemical nohesperIdIn 100mg
A flavonoid with diverse biological activities; inhibits osteoclast differentiation, bone resorption, activation of NF-κB and NFAT by RANKL, and calcium oscillations in vitro; in vivo administration protects ovariectomized mice from bone loss; reduces lipid accumulation in HepG2 cells and reverses hyperlipidemia in a mouse model of diet-induced obesity; increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in a mouse model of diabetes
Cayman Chemical PhenylacetylglycIn 50mg
A glycine conjugate of phenylacetate; decreases hypoxia-induced apoptosis in neonatal mouse cardiomyocytes at 100 µM; urine and plasma levels are increased in an amiodarone-induced rat model of phospholipidosis; reduces myocardial infarct size in a mouse model of ischemia-reperfusion injury
Cayman Chemical EtIocholnolon 50mg
An androgenically inactive metabolite of testosterone and androstenedione; potentiates GABA-induced chloride currents in HEK293 cells expressing rat α1β2γ2L subunit-containing GABAA receptors at 10 µM; protective against seizures induced by 6 Hz electroshock or PTZ (ED50s = 76.9 and 139 mg/kg, respectively); increases body temperature in rhesus macaques
Cayman Chemical aPIperIdInobutIophenonhyd 50mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical BromoACTAmIdoPEG3BocamIn 50mg
A PEGylated linker that contains a Boc protecting group
Cayman Chemical 1S 3S3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical LarIxyl Acetate 50mg
A diterpenoid; inhibits the activity of TRPC6 (IC50 = 0.58 µM receptor) and is selective for TRPC6 over TRPC3 (IC50 = 6.83 µM), as well as over nine additional TRP channels at 10 µM; reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by SNI
Cayman Chemical ChlorphensIn Carbamate 50mg
A muscle relaxant; decreases the dorsal root potential induced by a current-stimulated ventral root, as well as L-glutamate-induced motor neuron discharges, in isolated frog spinal cords at 1 mM; reduces the amplitude of polysynaptic responses in ipsilateral ventral root L5 induced by electrical stimulation of dorsal root L5 in spinalized rats at 50 mg/kg; decreases monosynaptic signal transfer from primary afferent fibers to motor neurons in the same animals at 50 mg/kg
Cayman Chemical DutasterIde 100mg
An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone at 0.045 and 0.756 mg/kg administered as a solution or in subcutaneous microspheres, respectively, daily for 28 days; also decreases prostate weight in a transgenic model of prostate cancer
Cayman Chemical CnabIgerol 50mg
An analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications
Cayman Chemical Hexnoyl GlycIn 50mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation
Cayman Chemical nlumbo nucIfera Lotusn 50mg
An alkaloid with diverse biological activities; increases cAMP levels in rat myocardium at 0.1-3 µM and cGMP levels in rabbit corpus cavernosum in a concentration-dependent manner; prevents doxorubicin-induced lipid peroxidation in H9c2 embryonic rat cardiomyocytes; increases LVP, LVEDP, and SAP in anesthetized rats at 5 mg/kg
Cayman Chemical -O-Desmethyl VenlafaxIn 50mg
An active metabolite of venlafaxine; inhibits NET and SERT (IC50s = 47.3 and 531.3 nM, respectively); selective for NET and SERT over 50 non-transporter targets; increases extracellular NE in the male rat hypothalamus and 5-HT in the same region when used in combination with WAY-100635; reduces immobility time in the forced swim test in a rat model of cognitive deficits and depression induced by MI when compared with MI-vehicle control animals 16 weeks following MI; improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI
Cayman Chemical Linolenic ACD 100mg
γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Cayman Chemical RS 25344hydrochlorIde 100mg
A PDE4 inhibitor (IC50 = 0.3 nM); selective for PDE4 over PDE1, -2, and -3 (IC50s = >100 µM for all); inhibits concanavalin A-induced IL-5 release and LPS-induced TNF-α release in isolated human PBMCs (EC50s = 0.3 and 5.4 nM, respectively)